大鼠射频损毁治疗靶点脑局部血氧饱和度(SO2)变化特性研究

J4 ›› 2009, Vol. 26 ›› Issue (5): 631-635.

大鼠射频损毁治疗靶点脑局部血氧饱和度(SO2)变化特性研究

瞿犇¹ 钱志余¹ 毛雯岚¹ 张正雄²

1南京航空航天大学生物医学工程系南京 210016;
2东南大学附属中大医院神经外科南京 210009

出版日期:2009-09-28 发布日期:2009-08-27
通讯作者: 钱志余，男，汉族，江苏省南通人，南京航空航天大学教授，博士生导师. E-mail:zhiyu@nuaa.edu.cn
作者简介:瞿犇，男，1985年生，汉族，湖北省洪湖市人，南京航空航天大学生物医学工程专业硕士究生，研究方向：生物医学光子学，E-mail:billben@163.com
基金资助:
国家自然科学基金（30671997）

Research of change in radio-frequency damage of hemoglobin oxygen saturation (SO2) of rat’s brain tissue

Qu Ben¹, QIAN Zhi-Yu¹, MAO Wen-Lan¹, Zhang Zheng-Xiong²

1Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016;
2 Department of Neurosurgery, Zhongda Hospital, Southeast University, Nanjing 210009

Published:2009-09-28 Online:2009-08-27

摘要/Abstract

摘要：

神经外科脑毁损术中靶点局部生理参数实时监控非常重要，目前手术疗效还没有一种可靠的实时评估指标，我们将对此进行初步探索。采用 SD大鼠为实验对象，对大鼠脑部治疗靶点进行局部射频毁损，利用微创近红外光谱技术实时测量局部血氧饱和度，考察其毁损过程中的变化规律。实验结果表明血氧饱和度在可逆与不可逆毁损时表现出不同的变化特性，通过对实验数据的统计分析，找到了一些基本规律，这些结果对立体定向射频毁损实时疗效评估具有一定的参考价值。

关键词: 医用光学与生物技术, 射频毁损, 血氧饱和度, 可逆毁损, 近红外

Abstract:

During the neurosurgery brain damage surgery, the region of the target’s physiological parameters real-time monitoring is very important. There isn’t a credible method on real-time evaluation rule at present. We will do some elementary research in this aspect. We choose SD rats as experiment object. We damage the target of treatment local of rats brain with radio-frequency, and use of minimally invasive Near-infrared technology measure hemoglobin oxygen saturation on real-time. We study the changes in the process of radio-frequency damage. We studies the different changes of hemoglobin oxygen saturation appearance in reversible damage and irreversible damage. At the same time, we find out some basic law on the analysis a large number of experiment parameters. The results have some efficacy of certain reference value in future damage of stereotactic radio-frequency real-time assessment.

Key words: medical optics and biotechnology, radio-frequency damage, hemoglobin oxygen saturation (SO2) , reversible damage, near-infrared

瞿犇钱志余毛雯岚张正雄. 大鼠射频损毁治疗靶点脑局部血氧饱和度(SO2)变化特性研究[J]. J4, 2009, 26(5): 631-635.

Qu Ben, QIAN Zhi-Yu, MAO Wen-Lan, Zhang Zheng-Xiong. Research of change in radio-frequency damage of hemoglobin oxygen saturation (SO2) of rat’s brain tissue[J]. J4, 2009, 26(5): 631-635.

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