J4 ›› 2011, Vol. 28 ›› Issue (2): 197-201.

• 第二届全国光学青年学术论坛论文选登 • 上一篇    下一篇

高灵敏度振荡场生物传感器的理论与实验研究

肖平平1,胡红武1,殷澄2,曹庄琪2   

  1. 1 宜春学院物理科学与工程技术学院,江西 宜春 336000;
     2上海交通大学物理系,区域光纤通信网和新型光通信系统国家重点实验室,上海 200240
  • 出版日期:2011-03-28 发布日期:2011-03-03
  • 通讯作者: 曹庄琪(1945-),上海人,教授,主要从事导波光电子器件的研究。 E-mail:zqcao@sjtu.edu.cn
  • 作者简介:肖平平(1972-),江西宜春人,博士生,副教授,主要从事计算机、光通信、导波光学、集成光学、光电子器件等方面的研究。E-mail: xpp7967@163.com
  • 基金资助:

    国家自然科学基金(60978056),江西省教育厅(JXJG-08-14-12)资助课题

Theoretical and experimental investigation on high sensitivity oscillating field biosensor

XIAO Ping-ping1, HU Hong-wu1, YIN Cheng2, CAO Zhuang-qi 2   

  1. 1 School of Physics Science and Engineering Technology, Yichun University, Yichun 336000, China;
    2 Department of Physics, State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems, Shanghai Jiaotong University, Shanghai 200240, China
  • Published:2011-03-28 Online:2011-03-03

摘要:

利用双面金属包覆波导中的超高阶导模对导波层折射率极其敏感的特性,提出一种新型的生物传感器。与传统的表面等离子共振、泄漏波导以及反对称波导等消逝场生物传感器相比,该传感器的待测样品放置在导波振荡场中,样品折射率的微小变化都将引起输出光强的极大改变,从而极大提高了传感器的灵敏度和分辨率。初步的实验结果显示在现有噪声水平下至少能够分辨1ppm的葡萄糖溶度改变。预计该传感器将在环境监测、食品安全、生物医学和疾病诊断等领域有着极其广泛的应用前景和巨大的市场潜力。

关键词: 光波导, 超高阶导模, 灵敏度, 生物传感器

Abstract:

A novel oscillating field biosensor was proposed utilizing ultrahigh-order modes excitated in a symmetrical metal cladding waveguide (SMCW). Different from the conventional biosensors, such as surface plasmon resonance sensor (SPRS), leaky mode waveguide sensor (LWS) and reverse symmetry waveguide sensor (RSWS), the sample is placed inside the guiding layer. Since the guiding layer supports a high intensity oscillating field, the intensity of output light is rather sensitive to the tiny variation of refractive index, which leads to very high sensitivity and resolution. Based on the noise level, 1ppm variation of the glucose solution has been detected in our experiment. The proposed scheme is expected to have a wide application and promising future in various biomedical detections.

Key words: waveguide optics, ultrahigh-order mode, sensitivity, biosensor

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