Research of absorption coefficient of biological tissues in laser induced interstitial thermotherapy

J4 ›› 2011, Vol. 28 ›› Issue (1): 91-95.

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Research of absorption coefficient of biological tissues in laser induced interstitial thermotherapy

WANG Jin-yang¹, QIAN Zhi-yu¹, QIAN Ai-ping², Lv Cao-jun², WANG Dong³, HUA Guo-ran²

1 Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China；
2 Department of Mechanical Engineering, Nantong University, Nantong 226019, China；
3 Zhongda Hospital, Southeast University, Nanjing 210009, China

Received:2010-04-13 Revised:2010-06-06 Published:2011-01-28 Online:2011-01-14

Abstract

Abstract:

The feasibility of real-time monitoring in laser induced interstitial thermotherapy（LITT） of biological tissues using near infrared spectrum technique is explored and validated. In vitro liver and rats with subcutantaneous implanted tumor models were chosen as experiment objects. Changes of absorption coefficient of tissue are real-time measured by near infrared spectrum system in laser induced interstitial thermotherapy .The result indicates that absorption coefficient has some variations during LITT. The change law of absorption coefficient in vitro livers experiments is significant. It slowly goes up under low power, and rises greatly based on high power when biological tissues reach certain temperature(around 50℃) . The change laws of absorption coefficient during tumor experiments is different according to characteristics of tumor tissue which can be used for future clinical treatment. Experimental results show that absorption coefficient has valuable reference as a real-time monitoring factor in LITT of entity organizations, but it also needs further study as evaluating factor of the tumor treatment appraisal.

Key words: medical optics and biotechnology, laser induced interstitial thermotherapy, near infrared spectrum technique, absorption coefficient, real-time monitoring

CLC Number:

WANG Jin-yang, QIAN Zhi-yu, QIAN Ai-ping, Lv Cao-jun, WANG Dong, HUA Guo-ran . Research of absorption coefficient of biological tissues in laser induced interstitial thermotherapy[J]. J4, 2011, 28(1): 91-95.

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Research of absorption coefficient of biological tissues in laser induced interstitial thermotherapy

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