Research progress of THz-ATR technology for detecting 
biomedical samples

doi:10.3969/j.issn.1007-5461.2023.03.003

Abstract

Abstract: THz-attenuated total reflection (THz-ATR) spectral detection technology for water-containing samples has the advantages of no labeling, no ionization and high detection sensitivity. It has great application potential in the qualitative and quantitative detection of disease markers, so it is of great practical significance for the early diagnosis and staged diagnosis and treatment of major diseases. On the basis of a brief introduction to the basic principles of THz-ATR technology for the detection of aqueous samples, the application of THz-ATR spectroscopy detection technology with different radiation sources in biomedical detection is analyzed and compared in detail. Finally, the research status and future development trend of THz-ATR spectral detection technology are briefly summarized.

Key words: spectroscopy, THz-ATR spectral detection, aqueous samples, qualitative identification, quantitative detection

CLC Number:

O433

WANG Haiqing , , SHI Wei . Research progress of THz-ATR technology for detecting biomedical samples[J]. Chinese Journal of Quantum Electronics, 2023, 40(3): 319-332.

References

[1]Wang L, Wu X, Peng Y, et al.Quantitative analysis of homocysteine in liquid by terahertz spectroscopy[J].Biomedical Optics Express, 2020, 11(5):2570-2577 [2]Shi W, Wang Y, Hou L, et al.Detection of living cervical cancer cells by transient terahertz spectroscopy[J].Journal of Biophotonics, 2021, 14(1):e202000237- [3]Liao Y, Zhang M, Tang M, et al.Label-free study on the effect of a bioactive constituent on glioma cells in vitro using terahertz ATR spectroscopy[J].Biomedical Optics Express, 2022, 13(4):2380-2392 [4] Torii T, Chiba H, Tanabe T, et al.Measurements of glucose concentration in aqueous solutions using reflected THz radiation for applications to a novel sub-THz radiation non-invasive blood sugar measurement method[J]. Digital health, 2017, 3: 2055207617729534.[J].Digital health, 2017, 3:2055207617729534- [5] Peng Y, Shi C, Zhu Y, et al.Terahertz spectroscopy in biomedical field: a review on signal-to-noise ratio improvement[J]. PhotoniX, 2020, 1: 1-18. [6]Naftaly M.Metrology issues and solutions in THz time-domain spectroscopy: Noise,errors,calibration[J].IEEE Sensors Journal, 2012, 13(1):8-17 [7] Peng Y, Shi C, Wu X, et al.Terahertz imaging and spectroscopy in cancer diagnostics: a technical review[J]. BME Frontiers, 2020. [8]Shumyatsky P, Alfano R R.Terahertz sources[J].Journal of biomedical optics, 2011, 16(3):033001-033001 [9]Hangyo M.Development and future prospects of terahertz technology[J].Japanese Journal of Applied Physics, 2015, 54(12):120101- [10]Hafez H A, Chai X, Ibrahim A, et al.Intense terahertz radiation and their applications[J].Journal of Optics, 2016, 18(9):093004- [11] Bogue R.Sensing with terahertz radiation: A review of recent progress[J]. Sensor Review, 2018. [12]Moriguchi Y, Tokizane Y, Takida Y, et al.High-average and high-peak output-power terahertz-wave generation by optical parametric down-conversion in MgO: LiNbO3[J].Applied Physics Letters, 2018, 113(12):121103- [13]Nawata K, Hayashi S, Ishizuki H, et al.Effective terahertz wave parametric generation depending on the pump pulse width using a LiNbO3 crystal[J].IEEE Transactions on Terahertz Science and Technology, 2017, 7(5):617-620 [14]Mu N, Yang C, Xu D, et al.Molecular pathological recognition of freshly excised human glioma using terahertz ATR spectroscopy[J].Biomedical Optics Express, 2022, 13(1):222-236 [15]Soltani A, Jahn D, Duschek L, et al.Attenuated total reflection terahertz time-domain spectroscopy: uncertainty analysis and reduction scheme[J].IEEE Transactions on Terahertz Science and Technology, 2016, 6(1):32-39 [16] Soltani A, Busch S F, Plew P, et al.THz ATR spectroscopy for inline monitoring of highly absorbing liquids[J]. Journal of Infrared, Millimeter, and Terahertz Waves, 2016, 37: 1001-1006. [17]Takagi S, Takahashi S, Takeya K, et al.Influence of delay stage positioning error on signal-to-noise ratio,dynamic range,and bandwidth of terahertz time-domain spectroscopy[J].Applied Optics, 2020, 59(3):841-845 [18]Qiao X, Zhang X, Ren J, et al.Mean estimation empirical mode decomposition method for terahertz time-domain spectroscopy de-noising[J].Applied Optics, 2017, 56(25):7138-7145 [19]Hirori H, Yamashita K, Nagai M, et al.Attenuated total reflection spectroscopy in time domain using terahertz coherent pulses[J].Japanese journal of applied physics, 2004, 43(10A):L1287- [20] Cherkasova O P, M.Nazarov M, Shkurinov A P, et al. Terahertz spectroscopy of biological molecules[J]. Radiophysics and Quantum Electronics, 2009, 52: 518-523. [21] Smolyanskaya O A, Chernomyrdin N V, Konovko A A, et al.Terahertz biophotonics as a tool for studies of dielectric and spectral properties of biological tissues and liquids[J]. Progress in Quantum Electronics, 2018, 62: 1-77. [22] Son, Joo-Hiuk, ed.Terahertz biomedical science and technology [M]. CRC Press, 2014.153-168 [23] Naito H, Ogawa Y, Shiraga K, et al.Inspection of milk components by terahertz attenuated total reflectance (THz-ATR) spectrometer equipped temperature controller[C]//2011 IEEE/SICE International Symposium on System Integration (SII). IEEE, 2011: 192-196. [24]Suhandy D, Suzuki T, Ogawa Y, et al.A quantitative study for determination of glucose concentration using attenuated total reflectance terahertz (ATR-THz) spectroscopy[J].Engineering in Agriculture, Environment and Food, 2012, 5(3):90-95 [25]Arikawa T, Nagai M, Tanaka K.Characterizing hydration state in solution using terahertz time-domain attenuated total reflection spectroscopy[J].Chemical Physics Letters, 2008, 457(1-3):12-17 [26]Takebe G, Kawada Y, Akiyama K, et al.Evaluation of drug crystallinity in aqueous suspension using terahertz time-domain attenuated total reflection spectroscopy[J].Journal of Pharmaceutical Sciences, 2013, 102(11):4065-4071 [27] Shiraga K, Ogawa Y, Suzuki T, et al.Characterization of dielectric responses of human cancer cells in the terahertz region[J]. Journal of Infrared, Millimeter, and Terahertz Waves, 2014, 35: 493-502. [28]Takebe G, Kawada Y, Akiyama K, et al.Evaluation of drug crystallinity in aqueous suspension using terahertz time-domain attenuated total reflection spectroscopy[J].Journal of Pharmaceutical Sciences, 2013, 102(11):4065-4071 [29] Cherkasova O, Nazarov M, Shkurinov A.Noninvasive blood glucose monitoring in the terahertz frequency range[J]. Optical and Quantum Electronics, 2016, 48: 1-12. [30]Takeya K, Muto K, Ishihara Y, et al.Monitoring theophylline concentrations in saline using terahertz ATR spectroscopy[J].Applied Sciences, 2016, 6(3):72- [31]Zou Y, Liu Q, Yang X, et al.Label-free monitoring of cell death induced by oxidative stress in living human cells using terahertz ATR spectroscopy[J].Biomedical Optics Express, 2018, 9(1):14-24 [32] Zhang R, Yang K, Yang B, et al.Dielectric and double debye parameters of artificial normal skin and melanoma[J]. Journal of Infrared, Millimeter, and Terahertz Waves, 2019, 40: 657-672. [33]Tang M, Zhang M, Xia L, et al.Detection of single-base mutation of DNA oligonucleotides with different lengths by terahertz attenuated total reflection microfluidic cell[J].Biomedical Optics Express, 2020, 11(9):5362-5372 [34] Akiyama K, Horita K, Sakamoto T, et al.Monitoring the progress of lactic acid fermentation in yogurt manufacturing using terahertz time-domain–attenuated total-reflection spectroscopy[J]. Journal of Infrared, Millimeter, and Terahertz Waves, 2019, 40: 1160-1167. [35]Wang Y, Jiang Z, Xu D, et al.Study of the dielectric characteristics of living glial-like cells using terahertz ATR spectroscopy[J].Biomedical Optics Express, 2019, 10(10):5351-5361 [36] Cao Y, Chen J, Huang P, et al.Inspecting human colon adenocarcinoma cell lines by using terahertz time-domain reflection spectroscopy[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 211: 356-362. [37] Hu M, Tang M, Wang H, et al.Terahertz, infrared and Raman absorption spectra of tyrosine enantiomers and racemic compound[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 254: 119611. [38] Zhou J, Wang X, Wang Y, et al.A novel THz molecule-selective sensing strategy in aqueous environments: THz-ATR spectroscopy integrated with a smart hydrogel[J]. Talanta, 2021, 228: 122213. [39]Liao Y, Zhang M, Tang M, et al.Label-free study on the effect of a bioactive constituent on glioma cells in vitro using terahertz ATR spectroscopy[J].Biomedical Optics Express, 2022, 13(4):2380-2392 [40] Shi W, Li C, Wang H, et al.Quantitative detection of THz-ATR spectra of aqueous samples under strong-field terahertz wave[J]. Iscience, 2023, 26(1).

Research progress of THz-ATR technology for detecting biomedical samples

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