Brief Introduction to Spectral and Spectral Imaging Technology’s Application in Biomedicine

Abstract

Abstract:

Spectroscopy Technology and spectral imaging technology have very broad application prospects in the biomedical field because of their obtainment of target's chemical composition information. Latest development of seven applications of spectra and spectral imaging technology in biomedical field were introduced. Among them, applications of fluorescent multi-label colocalization, spectral karyotying and ocular pathology diagnosis are matured and have been used clinically. Although with clinical significance, applications of spectral imaging cancer detection, bio-chip testing, nondestructive glucose and Raman cancer detection are still in the early stages of development. Because above applications have lower accuracy of detection or poorer universality, and they still need further research.

Key words: Spectroscopy, Biomedical Application, Optical Detection, Spectral Imaging

CLC Number:

O433.4

YU Cui-rong WANG Xin-quan QI Min-jun XIA Wei-wei. Brief Introduction to Spectral and Spectral Imaging Technology’s Application in Biomedicine[J]. J4, 2015, 32(6): 641-647.

References

[1] John L. Smith.The Pursuit of Noninvasive Glucose: “Hunting the Deceitful Turkey”[EB/OL]. http://www.mendosa.com/The%20Pursuit%20of%20Noninvasive%20Glucose%203rd%20Edition.pdf, 2013/2014-11-25.
[2] Chi-Fuk So，Kup-Sze Choi，Thomas KS Wong，et al.Recent advances in noninvasive glucose monitoring[J]. Medical Devices: Evidence and Research, 2012, 5: 45–52.
[3]Huang Lan, Ding Haishu, Wang Guangzhi.The Preliminary Study on Noninvasive Detection Using NIR Diffusion Reflectance Spectrum for Monitoring Blood Glucose[J].光谱学与光谱分析, 2002, 22(3):387-391
[4] Institute of Automation, Chinese Academy of Sciences.NIR Spectral Transmission Method and Device of Human Blood Glucose Noninvasive Measurement (无创测量人体血糖的近红外光谱透射方法及装置)[P]. China: ZL 101799412 B, 2012.04.25
[5]Li Qingli, Liu Jieqiang, Li Xiang.Development of Human Blood Glucose Noninvasive Measurement System Based on Near Infrared Spectral Technology[J].光谱学与光谱分析, 2012, 32(3):642-646
[6]Sigurdur S, Pettr A P, Lars K H, et al.Detection of skin cancer by classification of Raman Spectral[J].IEEE Transactions on Biomedical Engineering, 2004, 51(10):1784-1794
[7]Yamazaki H, Kamin S, Kohda E, et al.The Diagmosis of Lung cancer using 1064nm excited near-infrared multichannel raman spectroscopy[J].Radiat Med, 2003, 21(1):1-6
[8]Haka AS, Volynskava Z, Gardecki JA, et al.Diagnosing breast cancer using Raman spectroscopy: prospective analysis[J].Journal of Biomed Opt, 2009, 14(5):054023-
[9] Jakub Surmacki, Jacek Musial, Radzislaw Kordek, et al.Raman imaging at biological interfaces applications in breast cancer diagnosis[J]., 2013, 12:-
[10]Yao Shuxia, Zhao Yuanli, Zhang Lu, et al.Raman Scattering Spectra of Breast Histological Sections[J].河南预防医学杂志, 2004, 15(3):132-134
[11] Wang Yanjun, Yao Huilu, Wang Guiwen, et al.Laser Tweezers Raman Spectroscopy Analysis of Liver Cancer Tissue[J]. [J].光谱学与光谱分析, , :-
[12](光谱学与光谱分析), 2009, 29(07): 1881-1883.
[13]Meng Lingjing, Ji Xiaolu, Li Zida, et al.Study on Raman Imaging of Single liver cancer cell[J].激光与光电子学进展, 2011, 48(2):021703-
[14]Hu Chengxu, Zheng Chao, Zhang Haipeng, et al.Study on Fresh Breast Tissues by Near-infrared Raman Spectroscopy[J].高等学校化学学报, 2013, 34(12):2721-2727
[15]Li Qingli.Progress in the Studies of Medical Spectral Imaging Technique[J].影像科学与光化学, 2008, 26(6):507-515
[16] Levenson R M, Cronin P J, Harvey N R.Spectral Imaging and Biomedicine: New Devices, New Approaches[C]. Proceedings of the 31st Applied Imagery Pattern Recognition Workshop(AIPR’02), 2002, 105-111.
[17] Talbot C B, Benninger R K P, Beule P D, et al.Application of Hyperspectral Fluorescemce Lifetime Imaging to Tissue Autofluorescence: Arthritis[C]. Diagnostic Optical Spectroscopy in Biomedicine III, Proc. of SPIE. Bellingham: International Society for Optical Engineering, 2005, 5862:58620T-1
[18]Anwer M.Hui Li,Fazlay Faruque,et alUse of Hyperspectral Imaging to Distinguish Normal,Precancerous,and Cancerous Cells[J].American Cancer Society, 2008, 114(1):13-21
[19]Hamed Akbari, Luma V.H.,David MS,et al. Hyperspectral imaging and quantitative analysis for prostate cancer detection[J].Journal of Biomedical Optics, 2012, 17(7):076005-
[20] G.L. Lu, Luma Halig, D.S. Wang, et al. Spectral-Spatial Classification Using Tensor Modeling for Cancer Detection with Hyperspectral Imaging[J]. Proc SPIE. Mar 21, 2014; 9034: 903413.
[21]Afromowitz M A, Callis J B, Hemimbach D M, et al.Multispectral Imaging of Burn Wounds: A New Clinical Instrument for Evaluating Burn Depth[J].IEEE Trans. On Biomedical Engineering, 1988, 35(10):842-850
[22]Balas C.A novel optical imaging method for the early detection,quantitative grading,and mapping of cancerous and precancerous lesions of cervix[J].IEEE Trans. on Biomedical Engineering, 2001, 48(1):96-106
[23] Martinez L.A Non-invasive Spectral Reflectance Method for Mapping Blood Oxygen Saturation in Wounds[C]. Proceedings of the 31st Applied Imagery Pattern Recognition Workshop(AIPR’02), 2002, 112-116
[24] Kong S G, Du Z, Martin M, et al.Hyperspectral Fluorescence Image Analysis for Use in Medical Diagnostics[C]. Advanced Biomedical and Clinical Diagnositc Systems III. Proc. of SPIE, 2005, 5692: 21-28.
[25] Fan Shifu, Zhang Sixiang, Zhao Youquan, et al.Research and Design of Microscopic Fluorescent Spectral Imager[J]. Chinese Journal of Scientific Instrument
[26](仪器仪表学报)，2005, 26(10): 1056-1059.
[27]Jiang Yi, Zeng Libo, Wu Qiongshui, et al.Microscopic spectral imaging based on an acousto-optic tunable filter[J].光学技术, 2005, 31(2):193-195
[28]Xiao Gonghai, Shu Rong, Xue Yomgqi.Design of microscopic hyperspectral imaging system[J].光学精密工程, 2004, 12(4):367-372
[29]Xu Lixia, Wang Qinqin.Development of Chromosome Karyctype Analysis Technology[J].医学综述, 2009, 15(2):188-190
[30] Song Hualei, Chen Baojiang, Fang Qun, et al.Spectral karyotyping of seven prenatally detected marker chromosomes and complex chromosome aberrations[J]. Chinese Journal of Medical Genetics(中华医学遗传学杂志). 2012, 29(4): 1105-1108
[31] Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Science.Multispectral Imaging Scanner of Gene Chip(多光谱成像基因芯片扫描仪)[P]. China: ZL02111141.3, 2004-9-15.
[32]Zhao Kefu, Zhang Youlin, Kong Xianggui.Study of Applying Fluorescence Spectrum Imaging to Quantitative Assay of Proteins in Biochip[J].光谱学与光谱分析, 2008, 28(07):1603-1607
[33] The Institute of Optics and Electronics the Chinese Academy of Sciences.Multispectral Imaging System and Method of Fundus Retina based on Line Scanning (一种基于线扫描的眼底视网膜多光谱成像系统和方法)[P]. China: CN 102499635 A, 2012.06.20.
[34] Zeng Pan.Study on Hyperspectral Imaging Technology of Fundus in situ(眼底原位无创高光谱成像技术研究). [D]. Beijing: Chinese University Academy of Sciences, 2013.
[35] Li Xiaoxin.Multispectral Fundus Imaging For Screening and Diagnosis(眼底病的多光谱诊断和筛查)[M]. Beijing: Beijing science and Technology Press, 2014 .