量子电子学报 ›› 2023, Vol. 40 ›› Issue (3): 319-332.doi: 10.3969/j.issn.1007-5461.2023.03.003

• “太赫兹物理、器件与应用”专辑 II • 上一篇    下一篇

THz-ATR 技术检测生物医学样品的研究进展

王海青 1,2, 施 卫 1*   

  1. ( 1 西安理工大学理学院, 陕西省超快光电技术与太赫兹科学重点实验室, 陕西 西安 710048; 2 宝鸡文理学院物理与光电技术学院, 宝鸡市微纳光电子与太赫兹技术重点实验室, 陕西 宝鸡 721016 )
  • 收稿日期:2023-03-01 修回日期:2023-04-20 出版日期:2023-05-28 发布日期:2023-05-28
  • 通讯作者: E-mail: swshi@mail.xaut.edu.cn E-mail:E-mail: swshi@mail.xaut.edu.cn
  • 作者简介:王海青( 1987 - ) , 女, 陕西凤翔人, 博士生, 讲师, 主要从事THz生物样品检测方面的研究。E-mail: wwanghaiqing@163.com
  • 基金资助:
    科技部重点研发计划 ( 2017YFA0701005) , 国家自然科学基金面上项目 (51807161, 62075179)

Research progress of THz-ATR technology for detecting biomedical samples

WANG Haiqing 1,2 , SHI Wei 1*   

  1. ( 1 Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology, Xi'an 710048, China; 2 Baoji Key Laboratory of Micro-Nano Optoelectronics and Terahertz Technology, School of Physics and Opto-Electronic Technology, Baoji University of Arts and Sciences, Baoji 721016, China )
  • Received:2023-03-01 Revised:2023-04-20 Published:2023-05-28 Online:2023-05-28

摘要: 太赫兹衰减全内反射 (THz-ATR) 光谱法含水样品检测技术具有无标记、无电离以及检测灵敏度高等优点, 在疾病标志物的定性识别和定量检测方面具有很大的应用潜力, 尤其对重大疾病的早期诊断和分阶段诊疗具有非常 重要的现实意义。在简要介绍THz-ATR技术检测含水样品基本原理的基础上, 通过分析与对比, 详细探讨了不同辐 射源的THz-ATR光谱检测技术在生物医学检测方面的应用, 最后简要归纳了THz-ATR光谱检测技术的研究现状及 未来发展趋势。

关键词: 光谱学, THz-ATR光谱检测, 含水样品, 定性识别, 定量检测

Abstract: THz-attenuated total reflection (THz-ATR) spectral detection technology for water-containing samples has the advantages of no labeling, no ionization and high detection sensitivity. It has great application potential in the qualitative and quantitative detection of disease markers, so it is of great practical significance for the early diagnosis and staged diagnosis and treatment of major diseases. On the basis of a brief introduction to the basic principles of THz-ATR technology for the detection of aqueous samples, the application of THz-ATR spectroscopy detection technology with different radiation sources in biomedical detection is analyzed and compared in detail. Finally, the research status and future development trend of THz-ATR spectral detection technology are briefly summarized.

Key words: spectroscopy, THz-ATR spectral detection, aqueous samples, qualitative identification, quantitative detection

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