近红外漫反射光谱在脱水剂脱水作用中的应用研究

J4 ›› 2010, Vol. 27 ›› Issue (6): 737-742.

近红外漫反射光谱在脱水剂脱水作用中的应用研究

戴丽娟¹ 花国然¹ 钱志余²

1 南通大学机械工程学院, 江苏南通 226019;
2 南京航空航天大学生物医学工程系江苏南京 210016

收稿日期:2010-01-26 修回日期:2010-03-09 出版日期:2010-11-28 发布日期:2010-11-19
通讯作者: 戴丽娟（1980.6—）女，博士，讲师，江苏南通人，主要从事生物组织光学方向的研究。 E-mail:dai.lj@ntu.edu.cn
基金资助:
国家自然科学基金 (30671997) 、江苏省自然科学基金(BK2008184)、南通市自然科学基金(K2009044)资助项目

Application of near infrared diffusion spectrum in effect of anhydration solution

DAI Li-Juan¹, HUA Guo-Ran¹, QIAN Zhi-Yu²

1 Colledge of Mechanics, Nantong University, Nantong 226019, China;
2 Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China

Received:2010-01-26 Revised:2010-03-09 Published:2010-11-28 Online:2010-11-19

摘要/Abstract

摘要：

分析了脑局部皮层的近红外漫反射光谱在研究脱水剂脱水作用中的可行性。将60只SD大鼠随机分成A、B、C三组，每组分别在尾静脉推注0.9% NaCl、20%甘露醇和7.5% NaCl(均为10ml/kg)，利用双光纤微创探头实时在位采集推注前后大鼠局部脑皮质的近红外漫反射光谱，分析光谱变化。结果：A组(0.9% NaCl)推注前后光谱未见明显变化，B组(20% 甘露醇)和C组(7.5% NaCl)推注后近红外区光谱斜率绝对值的相对变化率分别上升（5.5±1.2）%和（10.5±2.5）%，三组间的差别存在统计学意义。可见，脑局部皮质的漫反射光谱可作为一种评估脱水剂脱水作用的新方法。

关键词: 光谱学, 脱水作用评估, 近红外漫反射光谱, 脑皮层, 大鼠

Abstract:

The feasibility of the near infrared diffusion spectrum of local cortex for the study of effect of anhydration solution is analyzed. 60 SD rats were divided in random into three groups A, B, C, which are treated by 0.9% NaCl, 20% Mannitol and 7.5% NaCl through vena cava respectively. The near infrared diffusion spectrum of local cortex were collected continuously before and after the injection by a bifurcated fiber probe in vivo in a mini-invasive way, Then the changing rules of the spectrum were analyzed. Few changes of the spectrum were observed in the group A(0.9% NaCl), while, the relative changes of the absolute value of the spectrum slope between near infrared range were increased by (5.5±1.2)% for group B (20% mannitol) and (10.5±2.5)% for group C (7.5% NaCl). The differences among three groups make statistic sense (p<0.05). The near infrared diffusion spectrum of local cortex can be used as a new method for estimation of effect of anhydration solution.

Key words: spectroscopy, anhydrationeffect estimation, near infrared diffusion spectrum, cortex, rat

中图分类号:

戴丽娟花国然钱志余. 近红外漫反射光谱在脱水剂脱水作用中的应用研究[J]. J4, 2010, 27(6): 737-742.

DAI Li-Juan, HUA Guo-Ran, QIAN Zhi-Yu. Application of near infrared diffusion spectrum in effect of anhydration solution[J]. J4, 2010, 27(6): 737-742.

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